Statistical Analyses Primary Endpoint
- All bosentan vs placebo: ITT population
- AC-052-351: Student’s t-test
- AC-052-352: Mann-Whitney U-test
Management of patients with no valid assessment at the end of Period 1:
- Due to worsening PAH or death: walk test = 0 m
- AC-052-351: 1 placebo pt
- AC-052-352: 3 placebo, 2 bosentan 125 mg bid pts
- Due to other reasons: last value carried forward