Endothelin-1 (ET-1)
- Belongs to a family of 21-amino acid peptides
- Synthesized and secreted by endothelial cells
- Acts via 2 receptors:
- ETA, vascular smooth muscle cells (SMC)
- ETB, vascular SMC, endothelial cells, fibroblasts
- Induces vasoconstriction, fibrosis, hypertrophy and hyperplasia
- Increases vascular permeability