RCA Assays and Clinical Data For a rAd-p53 in Cancer Patients

7/27/01


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Table of Contents

RCA Assays and Clinical Data For a rAd-p53 in Cancer Patients

RCA Assays and Clinical Data

Two Sources of RCA

RCA Sources – Cont’d.

RCA Testing by Field Today

RCA Bioassay is Quantal

SCH 58500 rAd-p53 Construct

Phase I/II Clinical Trials rAd-p53

Specifics of SP RCA Bioassay

Testing SCH 58500 rAd-p53 for RCA

Confidence in Detecting RCA

Amount of RCA in Clinical Materials

Analytical Testing Methods for Adenoviral Shedding

SCH 58500 Clinical Subjects Positive for Adenoviral Shedding

SCH 58500 Clinical Subject Population

Serological Monitoring Serum Anti-Adenovirus Titer

Summary Points

Backup Slides

SCH 58500 rAd-p53 Vector

PPT Slide

ELISA Enzyme-linked Immunosorbent Assay

FACS-Infectivity “Fluorescent Activated Cell Sorter” infectivity assay

FACS-RCA “Fluorescent Activated Cell Sorter” RCA assay

PCR for RCA

PPT Slide

PPT Slide

Author: Beth Hutchins