Assessing Drug Transfer into Breast Milk

7/20/01


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Table of Contents

Assessing Drug Transfer into Breast Milk

Four discussion points

1. Why do we need data?

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“No hard data” leads to formula-feeding by default

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“TDM” drug

Identifying contraindicated drug

2. What data do we need?

Exposure Index

3. Carrier-mediated systems

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Organic cation transporters

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4. Graded approach

“Level 0” Preclinical Study

“Level I” Clinical Study

“Level II” Clinical Study

Author: Shinya Ito