Perspectives on CNS Malignancies

6/29/01


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Table of Contents

Perspectives on CNS Malignancies

Introduction and Outline

Diagnosis of CNS Malignancies Current Practice and Possibilities

Morphologic Classification of CNS Neoplasms

CNS Parenchymal Neoplasms - "Glial phenotype"

CNS Parenchymal Neoplasms - "Neuronal and glial/neuronal Phenotype"

CNS Parenchymal Neoplasms - "Embryonal phenotype"

Neoplasms Arising in Accessory CNS structures

Neoplasms Arising in CNS Coverings

CNS Neoplasms Age of Patients Affected

Incidence of CNS neoplasms Adult >> Pediatric

Incidence of CNS neoplasms Pediatric >>Adult

Incidence of CNS neoplasms Pediatric (nearly exclusively)

Pathobiology of Neoplasia

Pathobiology of Neoplasia

Pathobiology of Neoplasia

Pediatric Neoplasms

Familial Syndromes Associated with CNS Neoplasms

Other ways of characterizing CNS malignancies

Rapidly Proliferating Neoplasms - Kill dividing cells

Infiltrating Neoplasms - Inhibit migration

Angiogenesis

TP53 mutations

Inhibit function of oncogenic signal transduction pathways

Inhibit function of oncogenic signal transduction pathways

Look at entire pathway - not just single component

Cautions

Author: Susan M. Staugaitis