Table of Contents
Perspectives on CNS Malignancies
Introduction and Outline
Diagnosis of CNS Malignancies – Current Practice and Possibilities
Morphologic Classification of CNS Neoplasms
CNS Parenchymal Neoplasms - "Glial phenotype"
CNS Parenchymal Neoplasms - "Neuronal and glial/neuronal Phenotype"
CNS Parenchymal Neoplasms - "Embryonal phenotype"
Neoplasms Arising in Accessory CNS structures
Neoplasms Arising in CNS Coverings
CNS Neoplasms – Age of Patients Affected
Incidence of CNS neoplasms – Adult >> Pediatric
Incidence of CNS neoplasms – Pediatric >>Adult
Incidence of CNS neoplasms – Pediatric (nearly exclusively)
Pathobiology of Neoplasia
Pathobiology of Neoplasia
Pathobiology of Neoplasia
Pediatric Neoplasms
Familial Syndromes Associated with CNS Neoplasms
Other ways of characterizing CNS malignancies
Rapidly Proliferating Neoplasms - Kill dividing cells
Infiltrating Neoplasms - Inhibit migration
Angiogenesis
TP53 mutations
Inhibit function of oncogenic signal transduction pathways
Inhibit function of oncogenic signal transduction pathways
Look at entire pathway - not just single component
Cautions
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