Inhibition of Protein Synthesis (2)

• Inhibition of peptidyl transferase activity

5S rRNA

Domain V

Domain II

Pocket: peptidyl transferase site

5S rRNA

5S rRNA

2058

752

V

II

V

II

Erythromycin A

Telithromycin

2058

752

30S

50S

O

O

O

-cladinose

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