PPT Slide

Drug Induced QT Prolongation

Preclinical Screeing

• In vitro ion channels effects
  • IKr - cloned HERG (HEK or AT-1 cells)
  • Ica & INa

• In vitro APD effects
  • Isolated myocytes (dog,rabbit,g. pig)
  • Purkinje fibers (dog,rabbit)
  • Papillary muscle (guinea pig)

• Wide range of concentrations (100-1000X)

• Wide range of rates

• Metabolites

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