Drug-Induced QT Interval Prolongation andTorsades de Pointes

5/16/01

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Table of Contents

Drug-Induced QT Interval Prolongation andTorsades de Pointes

Drug-Induced Torsades de Pointes

QT Prolongation & Torsades de Pointes

QT Prolongation & Torsades de Pointes

Drugs Which Prolong the QTc

QT Prolongation & Torsades de Pointes

Action Potential and Ionic Currents

Ventricular Action Potential

Mechanisms Of Drug - Induced QT Prolongation and Tdp

Torsades de Pointes

Torsades de Pointes

ECG - QT Interval

Automated QT and QTc Analysis

Rate-Corrected QT Interval (QTc)

QT Correction Formulae

Normal QTc Interval - Criteria

QT Intervals in Drug Induced TdP

TdP - High Risk Drugs (> 1%)

TdP - Low Risk Drugs (< 0.1%)

Drug-Induced Torsades de Pointes

Effect of EC K+ on Drug Induced IKr Block

CYP450 3A4 Inhibitors

Drug Induced Torsades de Pointes

QTc Changes with Terfenadine Effect of CYP3A4 Inhibition with Ketoconazole

Terfenadine (Seldane) 60 mg BID

Cisapride (Propulsid)

TdP: Multiple-Hit Hypothesis

Drugs Withdrawn for TdP

Evaluation of New Drugs - Risk Assessment

Drug-Induced TdP

Drugs Which Cause TdP

Drug Induced QT Prolongation

Author: Jeremy Ruskin