Table of Contents
Pediatric Subcommittee Presentation on Pharmacologic Control of Drooling
Issues for the Pediatric Subcommittee
Questions for the Pediatric Subcommittee
Division of Dermatologic and Dental Drug Products (DDDDP, HFD-540)
Agenda
Agenda (cont’d)
Autonomic Nervous System
Innervation of Salivary Glands
Reasons Drooling Requires Intervention
Other Cholinergic Effects
Summary
Summary (cont’d)
PPT Slide
PPT Slide
Drooling
Prevalence of Cerebral Palsy1
Prevalence of Drooling4
Reasons Drooling Requires Intervention
Reasons Drooling Requires Intervention
Methods Used to Control Drooling
Pharmacologic Control
Antimuscarinics
PPT Slide
PPT Slide
PPT Slide
Clinical Trials Necessary to Evaluate New Formulations
Clinical Studies Necessary to Determine Pediatric Dosing
PPT Slide
PPT Slide
Challenges of Conducting Clinical Trials in Children with Special Needs:
Efficacy Assessment
Efficacy Assessment
Safety Assessment
Safety Assessment
Conclusions
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