Interferon Monotherapy in ChildrenA Meta-analysis

• 11 manuscripts and 3 abstracts

• 270 treated children, 37 controls

• One of the controls cleared HCV RNA

• SVR in treated subjects 35% (0-73%)

  • 26% in genotype 1
  • 70% in genotype non-1

• Few controls, heterogeneous rx, publication bias

Jacobson KR, JPGN 2000;S123

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