Natural History of Perinatally Acquired HCV in Children

Sasaki, 1997: 3/15 at risk infants HCV RNA positive in first month

? only 1/15 infected at 16 months

Palomba, 1996: 7 HCV-infected infants born of HCV/HIV coinfected women ? all remained infected after 26-90 months

Bortolotti, 1997: 10 HCV-infected infants followed for 12-48 months

? 8/10 remained infected

Anecdotes: 2 perinatally-infected children developed cirrhosis by

age 11, 13 years

3 perinatally-infected children with decompensated cirrhosis

at 4, 6, 11 years - 2 born to HCV/HIV coinfected women

Zuccotti, 2000: 11 HCV-infected infants followed for 42-144 months ?

? 10/11 remained infected: