Table of Contents
Challenges and Considerations in Linking Adult and Pediatric Leukemias
Adult and Pediatric Leukemias
Adults have a worse prognosis!
Survival in Acute Leukemias
Evidence for Heterogeneity in ALL
Impact of Heterogeneity on ALL Therapy
Molecular Geno- and Phenotyping
CDNA Array in ALL
cDNA Array in ALL
What subsets of adult and pediatric leukemias might be appropriate for common therapeutic studies?
Acute Lymphoblastic Leukemia
Acute Myeloblastic Leukemia
The Era of Molecular Targeting
Can we develop a general principle that might guide the identification of biological subsets that would be suitable for study both in adults and children?
Examples of Biological Features that may be Shared by Adult and Pediatric leukemias
Challenges to the Design of Common Adult and Pediatric Leukemia Trials
Benefits of Designing and Implementing Common Adult and Pediatric Leukemia Trials
Cytogenetics in Adult and Pediatric ALL
Cytogenetics in Adult & Pediatric AML