Challenges and Considerations in Linking Adult and Pediatric Leukemias

6/20/01


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Table of Contents

Challenges and Considerations in Linking Adult and Pediatric Leukemias

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Adult and Pediatric Leukemias

Adults have a worse prognosis!

Survival in Acute Leukemias

ACUTE LEUKEMIAS

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Evidence for Heterogeneity in ALL

Impact of Heterogeneity on ALL Therapy

Technologic Advances

Cytogenetics

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Molecular Geno- and Phenotyping

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CDNA Array in ALL

cDNA Array in ALL

What subsets of adult and pediatric leukemias might be appropriate for common therapeutic studies?

Acute Lymphoblastic Leukemia

Acute Myeloblastic Leukemia

The Era of Molecular Targeting

Can we develop a general principle that might guide the identification of biological subsets that would be suitable for study both in adults and children?

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Examples of Biological Features that may be Shared by Adult and Pediatric leukemias

Challenges to the Design of Common Adult and Pediatric Leukemia Trials

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Benefits of Designing and Implementing Common Adult and Pediatric Leukemia Trials

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Summary

Cytogenetics in Adult and Pediatric ALL

Cytogenetics in Adult & Pediatric AML

Author: Malcolm Smith