Tenth Congressof theInternational PsychogeriatricAssociationNice, FranceSeptember 9 – 14, 2001Pharmacy and TherapeuticsCommitteeMild Cognitive Impairment:Definition, Diagnosis and Prognosis

3/16/01

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International Psychogeriatric Association

Tenth Congressof theInternational PsychogeriatricAssociationNice, FranceSeptember 9 – 14, 2001Pharmacy and TherapeuticsCommitteeMild Cognitive Impairment:Definition, Diagnosis and Prognosis

Mild Cognitive Impairment:A Broad Perspective

“The MCI diagnostic

“ The term MCI was first used in the description of GDS stage 3” 1, 2

Equilibrium and Limb Coordination in Mild Cognitive Impairment and Mild Alzheimer’s DiseaseFranssen, et al. J Am Geriatr Soc., 47: 463-469, 1999.

Can MCIbe clearly defined in a clinicalsetting?

Are there valid criteria for a diagnosis of MCI?

Can MCI bedistinguished fromAlzheimer’s diseaseand other causes of dementia?

What outcome measuresare appropriate to use in clinical drugtrials conducted in MCI?

Should clinical drug trials in MCIincorporate any specialfeatures in their design?

Can MCIbe clearly defined in a clinicalsetting?

Are there valid criteria for a diagnosis of MCI?

Can MCI bedistinguished fromAlzheimer’s diseaseand other causes of dementia?

What outcome measuresare appropriate to use in clinical drugtrials conducted in MCI?

Should clinical drug trials in MCIincorporate any specialfeatures in their design?

Author: FDA.CDER