Table of Contents
MILD COGNITIVE IMPAIRMENT UNRESOLVED ISSUES
MILD COGNITIVE IMPAIRMENT
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FDA QUESTIONS 1 and 2
MILD COGNITIVE IMPAIRMENT CRITERIA
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FDA QUESTION 4
Mild Cognitive Impairment (MCI)
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FDA QUESTION 5
PREDICTORS OF CONVERSION
MCI: Conversion to Dementia
NEUROIMAGING
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Proposed Sequence of Biochemical Progression in the Posterior cingulate VOI
UNRESOLVED ISSUES
Mild Cognitive Impairment CDR and GDS
CDR and GDS (means)
REFERENCE GROUPS
SOURCE OF SUBJECTS
CLINICAL HETEROGENEITY
FDA QUESTION 3
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SEMANTIC ISSUES
MCI CONCLUSIONS
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MAYO ALZHEIMER’S DISEASE RESEARCH CENTER
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Author: Ronald C. Petersen
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