MILD COGNITIVE IMPAIRMENT UNRESOLVED ISSUES

3/16/01


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Table of Contents

MILD COGNITIVE IMPAIRMENT UNRESOLVED ISSUES

MILD COGNITIVE IMPAIRMENT

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FDA QUESTIONS 1 and 2

MILD COGNITIVE IMPAIRMENT CRITERIA

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FDA QUESTION 4

Mild Cognitive Impairment (MCI)

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FDA QUESTION 5

PREDICTORS OF CONVERSION

MCI: Conversion to Dementia

NEUROIMAGING

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Proposed Sequence of Biochemical Progression in the Posterior cingulate VOI

UNRESOLVED ISSUES

Mild Cognitive Impairment CDR and GDS

CDR and GDS (means)

REFERENCE GROUPS

SOURCE OF SUBJECTS

CLINICAL HETEROGENEITY

FDA QUESTION 3

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SEMANTIC ISSUES

MCI CONCLUSIONS

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MAYO ALZHEIMER’S DISEASE RESEARCH CENTER

Author: Ronald C. Petersen