Penicillin Nonsusceptibility Among Isolates CausingInvasive Pneumococcal Disease*

Spika JS et al. J Infect Dis. 1991;163:1273-8

Breiman RF et al. JAMA. 1994;271:1831-5

Butler JC et al. J Infect Dis. 1996;174:986-93Cetron MS et al. ASM, 1997.AbstractMMWR. 1999;48:656-61Whitney CG et al. NEJM 2001; 343:1917-24

* Isolates obtained from patients of all ages.

0

5

10

15

20

25

30

1979–87

1991–92

1993–94

1995–96

1997

Collection year

Resistant isolates (%)

5.0

6.7

17.3

20.8

25.0

1998

24.0

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