True Salvage Patients
We have recently seen a number of industry conducted purported “salvage” trials with strong caveats e.g. no prior NNRTI exposure, or no more than two previous PIs
While we certainly do not deny the need of new therapies for these people, who may be facing their one last good opportunity, our priority is the triple-class exposed patient
It is in this subset of patients the most poignant dilemmas manifest, and the most innovative trial designs will be required