Concentration Controlled Trials
In the past few years, a sophisticated and nuanced set of complications have come to the forefront as potential key determinants of successful treatment, including
- Cytochrome p450 inhibition and/or induction,
- Protein binding,
- p-2 glycoprotein,
- Impaired gastrointestinal function
- Differences between intercellular and intracellular concentrations
- The effects of hepatitis and other co-morbidities
- Other drug and food interactions than those listed above