Treatment factors unique to pediatrics
Pharmacokinetics: vary with age, size, tanner staging
- Must understand dosing for 2.5 kg, 4 weeks old through 100kg, 14 years old
Dosing: volume, palatability (have you tasted liquid ritonavir?), frequency (school schedules)
Toxicities: may be easier or more difficult for children to tolerate drugs; many seem better tolerated but what will long term sequelae be? (lipid abnormalities, mitochondrial toxicities)