Three Comparisons

• Rofecoxib vs. naproxen:

  • include indications of RA and OA
  • driven by the VIGOR trial

• Rofecoxib vs. non-naproxen NSAIDs:

  • include only OA indications

• Rofecoxib vs. placebo:

  • include ALZ and BP indication
  • driven by the ALZ tirals

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