Table of Contents
Gastrointestinal Review Highlights of the VIGOR Trial
Outline of Presentation
VIGOR Study Design
Primary study hypotheses
Endpoint definitions
Confirmed Event PUB Any one of the following four clinical presentations
Confirmed Event PUB (continued)
Confirmed Event PUB (continued)
Confirmed Complicated Event PUB
Results
PPT Slide
Confirmed Complicated PUBs
Types of Confirmed PUBs
Subanalysis by Risk factor Prior history of PUB
Subanalysis by Risk factor Age
High risk populations
High risk populations
GI Risk in special populations Other questions
Generalizability of GI Safety
Data from phase IIb and III studies
Data from phase IIb and III studies
Meta-analysis of cumulative PUB IIb and III Studies
Conclusion of meta-analysis of phase IIb and III studies
Overall Conclusions
Overall Conclusions
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