Table of Contents
The biology of window period infections: implications for donor screening and inventory hold
Sources of residual risk
Events in early viral infection
Stages of Infectivity
Pre-ramp-up Viremia
Immunosilent carriers: chronic antibody negative carriers
Estimates of false negative test error rates in routine donor screening
Sources of window period data
Estimates for WPs from Exposure to Seroconversion Following Discrete Parenteral Exposures
HIV needlestick exposure
HIV markers during early infection
Time to Detection of Transfusion-Transmitted HCV Infection (n=28)
HCV markers during early infection
Duration of Viremic WPs Prior to SC Detectable by MD and ID-NAT *
PPT Slide
Low-Level Intermittent HCV Viremia Preceding Ramp-Up Phase
HCV: Pre-ramp up viremia
HBV markers during early infection
Window Period Viremia Parameters Derived from NAT Analysis of Plasma Donor Panels
HCV: immunosilent carriers
PPT Slide
Risk and risk reduction calculations
Interventions to decrease risk compared to single sample serologic screening
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Author: Dr Steven Kleinman
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