The biology of window period infections: implications for donor screening and inventory hold

11/30/01


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Table of Contents

The biology of window period infections: implications for donor screening and inventory hold

Sources of residual risk

Events in early viral infection

Stages of Infectivity

Pre-ramp-up Viremia

Immunosilent carriers: chronic antibody negative carriers

Estimates of false negative test error rates in routine donor screening

Sources of window period data

Estimates for WPs from Exposure to Seroconversion Following Discrete Parenteral Exposures

HIV needlestick exposure

HIV markers during early infection

Time to Detection of Transfusion-Transmitted HCV Infection (n=28)

HCV markers during early infection

Duration of Viremic WPs Prior to SC Detectable by MD and ID-NAT *

PPT Slide

Low-Level Intermittent HCV Viremia Preceding Ramp-Up Phase

HCV: Pre-ramp up viremia

HBV markers during early infection

Window Period Viremia Parameters Derived from NAT Analysis of Plasma Donor Panels

HCV: immunosilent carriers

PPT Slide

Risk and risk reduction calculations

Interventions to decrease risk compared to single sample serologic screening

Author: Dr Steven Kleinman