Pathophysiology of Sickle Cell Anemia: Hemoglobin S Polymerization

6/14/01


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Table of Contents

Pathophysiology of Sickle Cell Anemia: Hemoglobin S Polymerization

Red Blood Cells from Sickle Cell Anemia

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Deoxyhemoglobin S Polymer Structure

Determinants of Hemoglobin S Polymerization

Hemoglobin S Polymerization in SS Erythrocytes

SS Dense Cells Impair Filtration Even at High Oxygen Saturation

Mixtures of HbS with Other Hemoglobins Increase Deoxyhemoglobin Solubility

Hemoglobin Polymerization in AS and SS Erythrocytes

Impaired Filtration and Polymer Fraction

Defective Urine Concentrating Ability in Sickle Cell Trait

Hemoglobin Polymerization in Sickle Trait Erythrocytes

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Author: Philip D. Noguchi