Conclusions
Relationship between infectious units and RNA/DNA levels varies by stage of infection
During primary (pre-SC) infection, 1-10 gEq/mL plasma appears able to transmit infection
Ab+/NAT- donations must be presumed infectious (can’t d/c serology or reenter donors)
Need for future studies at international level
- animal transmission model systems
- donor lookback studies (prior units from NAT+ and Ab SC donors)
- investigation of donors in TA-recipient infections