Stages of TTVIs and infectivity
Post-SC
- Chronic seropositive carrier state
- Set-point viral load (NA vs Ag levels)
- Variable infectivity to NA/Ag ratio
- Defective viral particles
- Excess Ag production
- Neutralizing Ab
- Impact of unit storage and recipient susceptibility
- “Resolved” infection
- Sensitivity of NAT vs infectivity in blood?
- Persistence of infections virus in liver or other tissues
- Waning Ab titers w/ persistent cellular immune responses