Nucleic Acid Testing vs Infectivity

6/13/01


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Table of Contents

Nucleic Acid Testing vs Infectivity

NAT vs Infectivity

Stages of TTVIs and infectivity

Stages of TTVIs and infectivity

PPT Slide

Low-Level Intermittent HCV Viremia Preceding Ramp-Up Phase

Representative HIV Conversion Panels with Pre-Ramp-Up “Blip” Viremia (RNA “blip” observed in 7/19 informative panels)

PPT Slide

Stages of TTVIs and Infectivity

HCV RNA Production Rate and Linear Regression Model during Ramp-up Viremia

Individual Rates and Linear Regression Model of HIV RNA Production during Early Infection.

Individual Rates and Linear Regression Model of HBV DNA Production during Early HBV Infection

Window Period Viremia Parameters Derived from NAT Analysis of Plasma Donor Panels

Projections of HCV Window Period Reductions by MP / ID NAT Using the Linear Regression Model of HCV Production

Incremental WP Closure and Projected Yield (U.S.) of ID over MP-NAT Screening

PPT Slide

Relationship of Infectivity & Viral Load pre-SC Animal Models

Infectivity Early in HCV Infection Assessed by Transmission to Chimpanzees

Relationship of Infectivity & Viral Load pre-SC Human Transmission Data

HIV Test Results for Donor, Recipients in Singapore Transmission Case Robbins, et al. JAMA, 2000

Reactivity (+ / Total) of Donor Screening NAT assays on a Coded Plasma Panel of Singapore transmission case and controls Robbins, et al. JAMA, 2000

HCV Transmission by Blood Donation Negative by NAT Schüttler CG, et al. Lancet 2000; 355:41-2

HCV Transmission by Blood Donation Negative by NAT Schüttler CG, et al. Lancet 2000; 355:41-2

Donor directed lookback studies from NAT+/SC donors Roth et al. Lancet (submitted)

Relationship of Infectivity & Viral Load pre-SC Human Transmission Data

Analysis of Reported Post-Tx Cases in Japan Matsumoto et al. Transfusion 2001

Stages of TTVIs and infectivity

Stages of TTVIs and infectivity

Virologic/Serologic Profile – HCV Panel 6211

Time to Detection of Transfusion-Transmitted HCV Infection by Test

PPT Slide

HCV NAT-Positive Donor with fluctuating viremia during plateau-SC phase

Stages of TTVIs and infectivity

PPT Slide

Stages of TTVIs and infectivity

Rate of HCV Viremia (dHCV TMA) among Seropositive Subjects with Divergent Risk Factors and Immune Status

Systematic Review of Role of Polymerase Chain Reaction in Defining Infectiousness among People Infected with Hepatitis C Virus Dore GJ, Kaldor JM, McCaughan GW Br Med J 1997; 315:333-7

PPT Slide

HCV viral load in anti-HCV+ donors and outcome in recipients Operskalski et al. AABB 2001

Correlation of HIV NAT with Supplemental HIV Serological Data ARC 09/08/99 – 08/31/00

Characteristics of WB Pos/TMA Neg Samples identified by ARC NAT Screening

PPT Slide

HBV DNA Detection in anti-HBc+ HBsAg- US blood donations Kleinman et al. AABB 2001

Infectivity of HBV DNA PCR+, HBsAg-, anti-HBc+ blood Prince et al. Transfusion 2001

Infectivity of HBsAg (-) Hepatic Allografts with Antibodies to HBV Dodson, et al. Transplantation 1997;64:1582-4

Conclusions

Author: Michael P Busch