Table of Contents
Nucleic Acid Testing vs Infectivity
NAT vs Infectivity
Stages of TTVIs and infectivity
Stages of TTVIs and infectivity
PPT Slide
Low-Level Intermittent HCV Viremia Preceding Ramp-Up Phase
Representative HIV Conversion Panels with Pre-Ramp-Up “Blip” Viremia (RNA “blip” observed in 7/19 informative panels)
PPT Slide
Stages of TTVIs and Infectivity
HCV RNA Production Rate and Linear Regression Model during Ramp-up Viremia
Individual Rates and Linear Regression Model of HIV RNA Production during Early Infection.
Individual Rates and Linear Regression Model of HBV DNA Production during Early HBV Infection
Window Period Viremia Parameters Derived from NAT Analysis of Plasma Donor Panels
Projections of HCV Window Period Reductions by MP / ID NAT Using the Linear Regression Model of HCV Production
Incremental WP Closure and Projected Yield (U.S.) of ID over MP-NAT Screening
PPT Slide
Relationship of Infectivity & Viral Load pre-SC Animal Models
Infectivity Early in HCV Infection Assessed by Transmission to Chimpanzees
Relationship of Infectivity & Viral Load pre-SC Human Transmission Data
HIV Test Results for Donor, Recipients in Singapore Transmission Case Robbins, et al. JAMA, 2000
Reactivity (+ / Total) of Donor Screening NAT assays on a Coded Plasma Panel of Singapore transmission case and controls Robbins, et al. JAMA, 2000
HCV Transmission by Blood Donation Negative by NAT Schüttler CG, et al. Lancet 2000; 355:41-2
HCV Transmission by Blood Donation Negative by NAT Schüttler CG, et al. Lancet 2000; 355:41-2
Donor directed lookback studies from NAT+/SC donors Roth et al. Lancet (submitted)
Relationship of Infectivity & Viral Load pre-SC Human Transmission Data
Analysis of Reported Post-Tx Cases in Japan Matsumoto et al. Transfusion 2001
Stages of TTVIs and infectivity
Stages of TTVIs and infectivity
Virologic/Serologic Profile – HCV Panel 6211
Time to Detection of Transfusion-Transmitted HCV Infection by Test
PPT Slide
HCV NAT-Positive Donor with fluctuating viremia during plateau-SC phase
Stages of TTVIs and infectivity
PPT Slide
Stages of TTVIs and infectivity
Rate of HCV Viremia (dHCV TMA) among Seropositive Subjects with Divergent Risk Factors and Immune Status
Systematic Review of Role of Polymerase Chain Reaction in Defining Infectiousness among People Infected with Hepatitis C Virus Dore GJ, Kaldor JM, McCaughan GW Br Med J 1997; 315:333-7
PPT Slide
HCV viral load in anti-HCV+ donors and outcome in recipients Operskalski et al. AABB 2001
Correlation of HIV NAT with Supplemental HIV Serological Data ARC 09/08/99 – 08/31/00
Characteristics of WB Pos/TMA Neg Samples identified by ARC NAT Screening
PPT Slide
HBV DNA Detection in anti-HBc+ HBsAg- US blood donations Kleinman et al. AABB 2001
Infectivity of HBV DNA PCR+, HBsAg-, anti-HBc+ blood Prince et al. Transfusion 2001
Infectivity of HBsAg (-) Hepatic Allografts with Antibodies to HBV Dodson, et al. Transplantation 1997;64:1582-4
Conclusions
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