Incidence of Grade 4 Cytopenias by Baseline Rai Stage (from Baseline Grade 0-2)

Rai 0-II Rai III/IV

Cytopenia % (n/N) % (n/N)

Anemia 2.6% (1/38) 5.0% (5/101)

Thrombocytopenia 0 (0) 8.0% (6/75)

Neutropenia 12.5% (4/32) 46.1% (41/89)

Integrated Safety Database (N=149)

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