Summary of Clinical Benefit

Responders Non-Responders All Patients

Clinical Benefit n/N (%) n/N (%) n/N (%)

Resolution of

B-symptoms or fatigue 17/17 (100) 28/42 (66.7) 45/59 (76.3)

Resolution of

massive splenomegaly 9/10 (90.0) 7/19 (36.8) 16/29 (55.2)

Improvement in

WHO PS 8/20 (40.0) 9/49 (18.4) 17/69 (24.6)

Improvement in

anemia 11/15 (73.3) 14/36 (38.9) 25/51 (49.0)

CAM211 Clinical Benefit

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