Preclinical Animal Models in Gene Transfer Research

12/5/00


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Table of Contents

Preclinical Animal Models in Gene Transfer Research

Initial Steps in the Development of a New Gene Transfer Vector

Goals of Preclinical Bioactivity Studies in Animals

Goals of Preclinical Toxicology Studies in Gene Transfer Research

Goals of Biodistribution Studies in Gene Transfer Research

Questions to be Answered by Preclinical Pharm/Tox Studies

How are Preclinical Animal Data Relevant to Gene Transfer?

Animal Models are Useful to Study Potential Gene Transfer Vectors

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - Comparison of Vector Toxicity in Monkeys and Mice

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Case Study - How do Safety Data in Animal Models Compare to Humans?

Summary

Questions for the Committee

Questions for the Committee

Questions for the Committee

Author: Anne M. Pilaro, Ph.D.