Table of Contents
Preclinical Animal Models in Gene Transfer Research
Initial Steps in the Development of a New Gene Transfer Vector
Goals of Preclinical Bioactivity Studies in Animals
Goals of Preclinical Toxicology Studies in Gene Transfer Research
Goals of Biodistribution Studies in Gene Transfer Research
Questions to be Answered by Preclinical Pharm/Tox Studies
How are Preclinical Animal Data Relevant to Gene Transfer?
Animal Models are Useful to Study Potential Gene Transfer Vectors
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Using an Efficacy Model to Support Safety of Gene Transfer for Cancer
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - Comparison of Vector Toxicity in Monkeys and Mice
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Case Study - How do Safety Data in Animal Models Compare to Humans?
Summary
Questions for the Committee
Questions for the Committee
Questions for the Committee
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