Pathogenesis of Cystine Deficiency: Wasting Syndromes (Slide 2)

• AIDS, sepsis, major injury, trauma, cancer, chronic fatigue syndrome, Crohn’s disease, ulcerative colitis, and athletic over-training are associated with:

  • low cystine,
  • low glutamine,
  • elevated glutamate,
  • increased urea production, and
  • reduced natural killer (NK) cell activity.

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