“Defective Antigen Processing Correlates with a Low Level of Intracellular Glutathione”
“Therefore, low intracellular glutathione levels in antigen-presenting cells correlate with defective processing of antigen with disulfide bonds, indicating that this thiol may be a critical factor in regulating productive antigen processing.”
- Short, S., Eur. J. Immunol. 1996, Dec;26(12):3015-3020.
Most antigens are proteins with disulfide bonds. GSH reduces disulfide bonds. Low GSH prevents disulfide bond reduction.
1. RSSR’ + GSH ? RSH + GSSR’
2. GSSR’ + GSH ? GSSG + R’SH