PPT Slide

Apoptosis - HIV Infection

• Apoptosis is a morphologic finding resulting from the process of programed/activation induced cell death.

• Characterized by condensation of the nucleus and cytoplasm and a distinctive pattern of chromosomal DNA fragmentation.

• This process is of interest in HIV infection because it may be an important mechanism of CD4 T cell depletion. In HIV infection there are increased numbers of apoptotic cells.

• Several methods including flow cytometry can be used to enumerate these cells.

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