Need for New Therapies

12/11/00


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Table of Contents

Need for New Therapies

Highly Active Antiretroviral Therapy (HAART) alone is not adequate therapy for HIV disease.

Benefits of HAART

Annual Deaths in the CWRU John Carey Special Immunology Unit

HAART does not:

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Virologic failure

Treatment failure in the clinic (53% at 1 yr, n = 310)

Correlation Between Adherence* and Virologic Suppression† (N = 84)

Immunologic failure

Toxicities associated with HAART

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End organ disease

The frequent toxicity and failure of HAART to eradicate HIV is forcing a paradigm shift