Evidence to Date of CarcinogenicitySummary of Clinical Studies, SafeTNet and Literature

• ECL cell hyperplasia in humans, unlike rats, not linked to carcinoid tumors

• No apparent causal relationship with carcinoid tumors and other GI malignancies

• Contribution in H. Pylori infected subjects to the development of gastric mucosal atrophy, intestinal metaplasia and dysplasia not apparent

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