Drug-Drug Interactions
- Increased Absorption
- Digoxin, nifedipine (10% -26% increase)
- Decreased Absorption
- Ketoconazole, itraconazole (80% decrease)
- Inhibition of CYP2C19 and reduced clearance
- Diazepam, phenytoin, R-warfarin, tolbutamide (10-55% decrease)
- ‘Slow Metabolizers’ or people with underlying medical conditions may have pronounced changes