Table of Contents
The Application of Evidence-Based Medicine to Achieve Progress in Pediatric Oncology
Outline
Childhood Cancer
Age-Adjusted SEER Cancer Incidence, 1991-95, Reflecting Cancers Occurring among Adults
PPT Slide
Childhood Cancer Clinical Research
Justification for Separate Studies for Children with Cancer
Survival Rates Have Dramatically Improved for Children with Cancer
Remarkable Past Progress Leukemia Mortality 1950-96
Childhood Acute Lymphoblastic Leukemia (ALL) Survival Rates:1960-1996
Childhood Lymphoma Mortality 1950-97
Remarkable Past Progress NHL Survival Rates:1960-1996
Contributions of NCI-Supported Nationwide Clinical Trials System to Improved Outcome
Why Randomized Phase III Clinical Trials??
Why Randomized Phase III Clinical Trials??
Selection Bias in High-dose Chemotherapy (HDCT) Trials
NCI-Supported Clinical Research for Children with Cancer--Phase III Trials
NCI-Supported Clinical Research for Children with Cancer--Phase III Trials
Randomized Trials for Pediatric Acute Lymphoblastic Leukemia: CCG-1922
PPT Slide
From Phase I to Phase III--Ifosfamide/Etoposide for Ewing’s Sarcoma
Randomized Trials for Pediatric Cancers - Ewing’s Sarcoma
Randomized Trials for Pediatric Cancers - Ewing’s Sarcoma
Results from Recent Phase III Trials for Children with Cancer
Study Questions for Recently Completed/Ongoing Phase III Trials
PPT Slide
Risk-Adjusted Therapy: Classifying Patients by Prognosis
Risk-Adjusted Therapy: Classifying Patients by Prognosis
Risk-Adjusted Therapy: Assigning Treatment Based on Prognosis
Risk-Adjusted Therapy Requires the Identification of Reliable Prognostic Factors
Scope of NCI-Supported Pediatric Clinical Trials Program
Pediatric Clinical Trials Cooperative Groups
Children’s Oncology Group
Pediatric Cooperative Group Clinical Trials Program --Participating Researchers
Pediatric Cooperative Group Clinical Trials Program --Supported Structures 1
Pediatric Cooperative Group Clinical Trials Program --Supported Structures 2
Pediatric Cooperative Group Clinical Trials Program --Supported Structures 3
Survivors of Childhood Cancer
PPT Slide
Selected CCSS Analyses in Progress
Unmet Needs
PPT Slide
Moving Towards a New Era
Molecularly Targeted Therapies for Childhood Cancers--2000
Bcr-Abl as Target for Treatment of Philadelphia Chromosome Positive ALL
PPT Slide
Bcr-Abl as Target for CML and Ph+ ALL Therapy
Summary 1
Summary 2: Progress Depends on Collaboration and Cooperation
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