Dose response study of 13-cis-retinoic acid in acne vulgaris Jones, D.H., King, K., Miller, A.J. and Cunliffe, W.J. British Journal of Dermatology 108, 333-343, 1983
This study was performed prior to release of Accutane
76 subjects with moderate to severe acne were chosen for the study
Three of the subjects were excluded from the study as a result of clinical side effects which were described as being ‘dose-related’
The side effects suffered by these three patients have not been disclosed