Notice to Dermatologists following increased label warnings
Following the increased label warning applied in the UK and Ireland in
March/May 1998 Prof. W. Cunliffe and his colleague Dr. T. Chu produced
an information leaflet stating that roaccutane caused depression in only a
small number of patients and suggested that the acne itself is the cause of
‘Acne can occasionally cause depression. Clinical depresssion can cause
suicide. A very small number of patients on Roaccutane develop
clinical mood changes/psychotic symptomsand may develop clinical
A recent correspondance from a prominent UK Dermatologist stated that;
‘In the few tragic cases where Roaccutane has caused depression and lead to
suicide it is indeed difficult to justify the use of Roacutane’