Alternate Risk Factors
Nearly one-quarter million alcohol/substance abusers are amongst the 2.5 million of Accutane-exposed cohort
Many of these abusers are also comorbid with the 152,000 incident mood disorder cases or with people with depressive symptoms or different disease
The total numbers in the cohort with some form DSM-IV disorder may be up to 16-20% (up to 1/2 million) of the total cohort