MDD Morbidity During Any Six Month Exposure Period

2.5 MillionUS IndividualsAged 15-24 Years

182,500

30,500 +42,700

84,000

25,290

???

Major DSM IV Depressive Disorder(With acne estimates not available)

t1

t2

152,500Current Disease

240,000By History Only

2,107,000 No Disease

No Change or 80% Abated then35% Recur

35% Recur orNo Change

1. 2% incident cases or No change

?# of Accutane-Induced Cases

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