Summary of Efficacy (1)

• Study B301: clear evidence of efficacy

  • Significant treatment differences for SGA of relief
  • Consistent positive findings on secondary efficacy variables

• Study B351: although not statistically significant on prespecified primary efficacy endpoints, overall results strongly supportive of efficacy

  • Daily diary variables statistically significant in favor of tegaserod
  • Positive trends for all SGA assessments

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