Number of Months With Positive Response for SGA of Relief§

P value versus placebo

12 mg/d Study 4 mg/d (4-12 mg/d)

B351 Original SGA of relief .107 .047

B351 SGA of relief .353 .013*

B301 SGA of relief .008* < .001*

B307 SGA of relief .479 .008*

1

* Statistically significant with adjustment for multiple comparisons.

§ Primary analysis of alosetron data. Gastrointestinal Drug Advisory Committee meeting, November 16, 1999.

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