Baseline Characteristics

Variable (mean) B351 B301 B307

Abdominal discomfort/pain 63 60 61VAS score, mm

Bowel habit VAS score, mm 64 60 62

Days with significant 87 84 86abdominal discomfort/pain, %

Days with significant bloating, % 88 83 86

Number of bowel movements/week 5.7 5.4 6.2

Days without bowel movements, % 46 44 41

Days with hard stools, % 31 28 29

Stool consistency score 4.7 4.7 4.6

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