Patient Disposition

B351 B301 B307

Enrolled 1,093 1,122 1,163

Discontinued 292 (27) 240 (21) 313 (27)during baseline

Randomized 799 881 845

Completed 633 (79) 751 (85) 680 (80)

Discontinued during 166 (21) 130 (15) 165 (20)double-blind period

1

Patients, n (%)

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