Inclusion Criteria

1

• Males and females ? 18 years of age (B351: ? 12 years)

• Colon evaluated within last 5 years

• Rome criteria

Continuous or recurrent discomfort/pain in lower abdomen

in last 3 months

Discomfort/pain • Relieved by BM

(1 of 3) • Associated with change in frequency of BMs

• Associated with change in consistency of stool

? 25% of the time • < 3 BMs/week

(2 of 3) • Hard or lumpy stool

• Straining

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