5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod

3/16/01


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Table of Contents

5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod

5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod

Physiologic Distribution of Serotonin (5-Hydroxytryptamine, 5-HT)

Role of 5-HT in the GI Tract

Intrinsic Signaling Pathways

Extrinsic Signaling Pathways

5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod

Tegaserod

Pharmacologic Profile of Tegaserod

Tegaserod Triggers the Peristaltic Reflex

Neurotransmitter Release Induced by Tegaserod is Inhibited by Selective 5-HT4 Antagonist

Tegaserod-Induced Propulsion in Guinea Pig Colon

Tegaserod Stimulates Canine Small Bowel and Colonic Motility After IV Tegaserod

Tegaserod Stimulates Canine Colonic Motility and Transit

Effect of Tegaserod on Gastrointestinal Transit in Healthy Subjects

Colonic Filling at 6 Hours Effect of Tegaserod in C-IBS

Effect of Tegaserod on Colonic Transit in C-IBS

Summary : Motor Effects of Tegaserod

5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod

Visceral Sensitivity End-Points for Preclinical Studies in Small Animals

Effect of Tegaserod on Visceral Sensitivity in Cats

Dose-Dependent Inhibition by Tegaserod of Afferent Nerve Activity to Rectal Distension in Cats

Tegaserod Inhibits Abdominal Contractions in Response to Colorectal Distension in Awake Rats

Summary : Sensory Effects of Tegaserod

Summary

Author: Ray Hunziker / H.-J. Pfannkuche