Table of Contents
5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod
5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod
Physiologic Distribution of Serotonin (5-Hydroxytryptamine, 5-HT)
Role of 5-HT in the GI Tract
Intrinsic Signaling Pathways
Extrinsic Signaling Pathways
5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod
Tegaserod
Pharmacologic Profile of Tegaserod
Tegaserod Triggers the Peristaltic Reflex
Neurotransmitter Release Induced by Tegaserod is Inhibited by Selective 5-HT4 Antagonist
Tegaserod-Induced Propulsion in Guinea Pig Colon
Tegaserod Stimulates Canine Small Bowel and Colonic Motility After IV Tegaserod
Tegaserod Stimulates Canine Colonic Motility and Transit
Effect of Tegaserod on Gastrointestinal Transit in Healthy Subjects
Colonic Filling at 6 Hours Effect of Tegaserod in C-IBS
Effect of Tegaserod on Colonic Transit in C-IBS
Summary : Motor Effects of Tegaserod
5-HT4 Receptor Physiology and Pharmacodynamic Effects of Tegaserod
Visceral Sensitivity End-Points for Preclinical Studies in Small Animals
Effect of Tegaserod on Visceral Sensitivity in Cats
Dose-Dependent Inhibition by Tegaserod of Afferent Nerve Activity to Rectal Distension in Cats
Tegaserod Inhibits Abdominal Contractions in Response to Colorectal Distension in Awake Rats
Summary : Sensory Effects of Tegaserod
Summary
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Author: Ray Hunziker / H.-J. Pfannkuche
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