Building and Evaluating PK/PD Models
Evaluate PK/PD model by comparing outcome of trial simulations to actual data from trials in experienced patients
- Response variables: treatment failure and/or presence of genotypic or phenotypic resistance
- Must incorporate realistic estimates of drug-taking behavior into the simulation
- For the clinical trial used for comparison, actual measures of adherence would be preferable since the effect of different adherence patterns on resistance development is not known