PPT Slide
-
- For assessing the effect of PK and adherence variability, 400 subjects were simulated for 48 weeks for each of the six regimens, for a dose-time perturbation of 1.6 hr. Adherences with a beta distribution and with a mean of 81% and SD of 0.20 were used for BID regimens, and a mean of 84% and SD of 0.19 were used for QD regimens.