A PK/PD Model combines
- A model describing drug concentrations vs. time (PK) with
- A model describing the relationship of effect vs. concentration (PD), and
- A statistical model describing variation in intra- and inter-individual PK/PD models
to predict the time-course and variability of effect vs. of time.
Note: Only mechanistic PK/PD models can be relied upon for extrapolation (I.e., for prediction vs. description)