Remarks (2)

Based on PK-PD relationships, pharmacokinetic data can and should be used as a background for new formulations/dosing regimens, but clinical data are still essential given the modest information available at this moment.

Based on PK-PD relationships, pharmacokinetic data can and should be used as a background for new formulations/dosing regimens, but clinical data are still essential given the modest information available at this moment.