Remarks (1)
Models of PK-PD have largely not (yet) included sensitivity of the virus as a parameter.
When linking phenotypic data with pharmacokinetics: IC50 values should (if at all) rather be used than IC90 or IC95 values.
EC values should rather be established than IC values.
It would be interesting to know if the boosted PI-strategy overcomes the PK-PD relationships found with the unboosted strategy.